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KMID : 0363420160300040099
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Journal of Korean Oriental Pediatrics
2016 Volume.30 No. 4 p.99 ~ p.110
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A Review of the Treatment to Prevent Neonatal Jaundice - Based on Traditional Chinese Medicine
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Jeong Ju-Hui
Kang Ki-Wan
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Abstract
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Introduction: Jaundice is one of the most common conditions found in neonatal period. Phototherapy is one of the main
treatments for neonatal jaundice. However, several adverse effects of the phototherapy have been reported, including
DNA damage recently. Therefore, a variety of treatments have been conducted to shorten the duration of phototherapy. Meanwhile, it has been hardly tried to prevent neonatal jaundice, but diverse approaches have been tried in traditional Chinese medicine (TCM) for many years. Therefore, this study aims to analyze the studies for the treatments to prevent neonatal jaundice based on TCM.
Materials and Methods: Various literatures have been searched via CNKI, and PubMed using the terms “neonatal jaundice” (新生??疸, 胎黃, 胎疸) in category of 'Traditional Chinese Medicine', 'Traditional Chinese Medicinal Herbs' and 'Combination of Traditional Chinese Medicine With Western Medicine'. The search range included randomized controlled trials (RCTs), controlled clinical trials (CCTs), case reports, reviews and animal experiments published from 2013 to 2015.
Results: A total of 104 studies were found. 93 articles were excluded by reviewing the titles and abstracts. Out of the
remaining 11 studies, 9 articles were RCTs, 2 articles were CCTs. The treatment used in neonatal babies in the studies were, using herbal remedies (meditation 5, bath 3 and retention enema 1) and the acupressure. All treatments were initiated within the first 24-48 hours after their birth. Then, there was a study that the subjects taken the herbal medicine were women during pregnancy. The outcome assessments used were the serum total bilirubin (TB), transcutaneous bilirubin measurement (TCB), the incidence of the hyperbilirubinemia, the duration time of the jaundice. Especially, TB, TCB and the incidence of the hyperbilirubinemia have decreased significantly more than that of the control group in the most of the results. No severe adverse events were reported in all articles reviewed.
Conclusions: Conventional treatment such as, herbal medicine in TCM, seems to be the effective way to prevent neonatal
jaundice or hyperbilirubinemia. Therefore, the conventional treatment may be favorable choice for preventive treatment for neonatal jaundice
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KEYWORD
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Neonatal jaundice, Hyperbilirubinemia, Preventive medicine, Traditional chinese medicine, Herbal medicine
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